Reinstatement of Dapsone Following Hypersensitivity

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Reinstatement of dapsone following hypersensitivity.

Sir, Dapsone therapy can cause severe adverse reactions known as the sulphone or dapsone hypersensitivity syndrome (DS). The most common presenting symptom is a maculopapular or exfoliative rash confined to either the upper limbs or the forehead, but it can also be disseminated. The sequence of symptoms – dermatitis, lymphadenopathy notably along the posterior border of the sternomastoid muscle...

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Severe dapsone hypersensitivity syndrome.

Dapsone, a potent antiparasitic and anti-inflammatory compound, is mainly used in the treatment of leprosy and a variety of blistering skin diseases. It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome. We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome. The clinical presentation mimicked a vir...

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Dapsone hypersensitivity syndrome with myocarditis.

Drug hypersensitivity with myocarditis is known to occur with many drugs especially with antiepileptics, sulpha-compounds and daposne. Dapsone (4, 4 diaminodiphenyl sulphone) induced hypersensitivity is known to occur in about 2% of leprosy patients on treatment and an incidence of 1.66% in non-leprosy patients. We report this rare case of dapsone hypersensitivity syndrome in a girl on dapsone ...

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Severe dapsone hypersensitivity syndrome in a child

Dapsone (4,4'-diaminodiphenylsulfone, DDS), a potent anti-inflammatory agent, is widely used in the treatment of leprosy and several chronic inflammatory skin diseases. Dapsone therapy rarely results in development of dapsone hypersensitivity syndrome, which is characterized by fever, hepatitis, generalized exfoliative dermatitis, and lymphadenopathy. Here, we describe the case of an 11-year-ol...

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Hypersensitivity reactions to dapsone: a systematic review.

Dapsone is widely used in the treatment of leprosy and several chronic inflammatory dermatological conditions. Hypersensitivity reactions to dapsone are potentially fatal adverse drug reactions with unknown prevalence and risk factors. We performed a systematic review covering all reported cases of hypersensitivity reactions, in order to systematically summarize the published evidence on preval...

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ژورنال

عنوان ژورنال: Acta Dermato-Venereologica

سال: 2003

ISSN: 0001-5555

DOI: 10.1080/00015550310016706